To provide a better impression of average ca 2 spark fluorescence intensity before and after colchicine treatment, each image is also represented by its 3d projection.
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If coadministration of clarithromycin and colchicine is necessary in patients with normal renal and hepatic function, the dose of colchicine should be reduced.
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A published report described the disposition of colchicine 1 mg in young adult men and women patients who had end-stage renal disease requiring dialysis compared to patients with normal renal function.
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Since gout and hyperuricemia are associated with an increased cv risk, 2-4 it is important to consider whether colchicine might have value as a cv prevention measure in patients with gout, wrote daniel h solomon, md, mph, from brigham and women s hospital in boston and colleagues.
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Isoniazid can inhibit colchicine s metabolism via cyp3a4, resulting in increased colchicine exposure.
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colchicine also interferes with the inflammasome complex found in neutrophils and monocytes that mediates interleukin-1 il-1 activation.